Secondary metabolites from the liverwort Tylimanthus renifolius

Two new herbertane sesquiterpenoids, (−)-herbertene-1,12-diol and (−)-γ-herbertenol, a new aromadendrane, 9-acetoxy-10-hydroxyaromadendrane, a new rosane diterpenoid, 5,15-rosadiene-3,11-dione and a new phytane, 2 Z-phytene-1,15,20-triol, along with the known (−)-α-herbertenol have been isolated from the liverwort Tylimanthus renifolius. Several flavones and flavanones with an unsubstituted ring B were also identified. This is the first report of this class of flavonoids from the Hepaticae. All structures were elucidated by NMR spectroscopy. Two new herbertanes, a new aromadendrane, a new rosane, a new phytane along with ring B unsubstituted flavonoids have been isolated from the liverwort Tylimanthus renifolius. Their structures were elucidated by NMR spectroscopy.