Alginate/chitosan particulate systems for sodium diclofenac release
Alginate/chitosan particles were prepared by ionic gelation (Ca 2+ and Al 3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological p...
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| Veröffentlicht in: | International journal of pharmaceutics 2002-01, Vol.232 (1), p.225-234 |
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| container_title | International journal of pharmaceutics |
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| creator | González-Rodrı́guez, M.L Holgado, M.A Sánchez-Lafuente, C Rabasco, A.M Fini, A |
| description | Alginate/chitosan particles were prepared by ionic gelation (Ca
2+ and Al
3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH, while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed. |
| doi_str_mv | 10.1016/S0378-5173(01)00915-2 |
| format | Article |
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2+ and Al
3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH, while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/S0378-5173(01)00915-2</identifier><identifier>PMID: 11790506</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Alginate/chitosan beads ; Alginate/chitosan ratio ; Alginates - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Ca 2+ and Al 3+ ions ; Calorimetry, Differential Scanning ; Chemistry, Pharmaceutical ; Chitin - analogs & derivatives ; Chitin - chemistry ; Chitosan ; Diclofenac - chemistry ; Dissolution profiles ; Drug Carriers ; General pharmacology ; Glucuronic Acid ; Hexuronic Acids ; Hydrogen-Ion Concentration ; Medical sciences ; Microspheres ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Sodium diclofenac</subject><ispartof>International journal of pharmaceutics, 2002-01, Vol.232 (1), p.225-234</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-6e4df62d91224d149ae8b73cd01cca43b24147873a9f1505e9fbfca0eb9c7cad3</citedby><cites>FETCH-LOGICAL-c391t-6e4df62d91224d149ae8b73cd01cca43b24147873a9f1505e9fbfca0eb9c7cad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517301009152$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13444306$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11790506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-Rodrı́guez, M.L</creatorcontrib><creatorcontrib>Holgado, M.A</creatorcontrib><creatorcontrib>Sánchez-Lafuente, C</creatorcontrib><creatorcontrib>Rabasco, A.M</creatorcontrib><creatorcontrib>Fini, A</creatorcontrib><title>Alginate/chitosan particulate systems for sodium diclofenac release</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Alginate/chitosan particles were prepared by ionic gelation (Ca
2+ and Al
3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH, while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed.</description><subject>Alginate/chitosan beads</subject><subject>Alginate/chitosan ratio</subject><subject>Alginates - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Ca 2+ and Al 3+ ions</subject><subject>Calorimetry, Differential Scanning</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chitin - analogs & derivatives</subject><subject>Chitin - chemistry</subject><subject>Chitosan</subject><subject>Diclofenac - chemistry</subject><subject>Dissolution profiles</subject><subject>Drug Carriers</subject><subject>General pharmacology</subject><subject>Glucuronic Acid</subject><subject>Hexuronic Acids</subject><subject>Hydrogen-Ion Concentration</subject><subject>Medical sciences</subject><subject>Microspheres</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. 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Antiinflammatory agents</topic><topic>Ca 2+ and Al 3+ ions</topic><topic>Calorimetry, Differential Scanning</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chitin - analogs & derivatives</topic><topic>Chitin - chemistry</topic><topic>Chitosan</topic><topic>Diclofenac - chemistry</topic><topic>Dissolution profiles</topic><topic>Drug Carriers</topic><topic>General pharmacology</topic><topic>Glucuronic Acid</topic><topic>Hexuronic Acids</topic><topic>Hydrogen-Ion Concentration</topic><topic>Medical sciences</topic><topic>Microspheres</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Sodium diclofenac</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-Rodrı́guez, M.L</creatorcontrib><creatorcontrib>Holgado, M.A</creatorcontrib><creatorcontrib>Sánchez-Lafuente, C</creatorcontrib><creatorcontrib>Rabasco, A.M</creatorcontrib><creatorcontrib>Fini, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González-Rodrı́guez, M.L</au><au>Holgado, M.A</au><au>Sánchez-Lafuente, C</au><au>Rabasco, A.M</au><au>Fini, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alginate/chitosan particulate systems for sodium diclofenac release</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2002-01-31</date><risdate>2002</risdate><volume>232</volume><issue>1</issue><spage>225</spage><epage>234</epage><pages>225-234</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Alginate/chitosan particles were prepared by ionic gelation (Ca
2+ and Al
3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH, while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11790506</pmid><doi>10.1016/S0378-5173(01)00915-2</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2002-01, Vol.232 (1), p.225-234 |
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| language | eng |
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| subjects | Alginate/chitosan beads Alginate/chitosan ratio Alginates - chemistry Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Ca 2+ and Al 3+ ions Calorimetry, Differential Scanning Chemistry, Pharmaceutical Chitin - analogs & derivatives Chitin - chemistry Chitosan Diclofenac - chemistry Dissolution profiles Drug Carriers General pharmacology Glucuronic Acid Hexuronic Acids Hydrogen-Ion Concentration Medical sciences Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Sodium diclofenac |
| title | Alginate/chitosan particulate systems for sodium diclofenac release |
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