Alginate/chitosan particulate systems for sodium diclofenac release
Alginate/chitosan particles were prepared by ionic gelation (Ca 2+ and Al 3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological p...
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Veröffentlicht in: | International journal of pharmaceutics 2002-01, Vol.232 (1), p.225-234 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Alginate/chitosan particles were prepared by ionic gelation (Ca
2+ and Al
3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH, while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed. |
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ISSN: | 0378-5173 1873-3476 |
DOI: | 10.1016/S0378-5173(01)00915-2 |