Alginate/chitosan particulate systems for sodium diclofenac release

Alginate/chitosan particles were prepared by ionic gelation (Ca 2+ and Al 3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological p...

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Veröffentlicht in:International journal of pharmaceutics 2002-01, Vol.232 (1), p.225-234
Hauptverfasser: González-Rodrı́guez, M.L, Holgado, M.A, Sánchez-Lafuente, C, Rabasco, A.M, Fini, A
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Sprache:eng
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Zusammenfassung:Alginate/chitosan particles were prepared by ionic gelation (Ca 2+ and Al 3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH, while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(01)00915-2