The magnitude of signal errors introduced by ISIS in quantitative 31P MRS

The magnitude of signal errors introduced by ISIS in quantitative 31P MRS

It is well known that the quality of a quantitative 31P MRS measurement relies largely on the performance of the volume selection method, and that image selected in vivo spectroscopy (ISIS) suffers from contaminating signal caused mostly by T1 smearing. However, these signal errors and their magnitu...

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Veröffentlicht in:Magma (New York, N.Y.) N.Y.), 2002-03, Vol.14 (1), p.30-38
Hauptverfasser: Ljungberg, Maria, Starck, Göran, Vikhoff-Baaz, Barbro, Alpsten, Magne, Ekholm, Sven, Forssell-Aronsson, Eva
Format: Artikel
Sprache:eng
Schlagworte:
Brain - pathology
Humans
Magnetic Resonance Spectroscopy - instrumentation
Magnetic Resonance Spectroscopy - methods
Phantoms, Imaging
Phosphorus - chemistry
Reproducibility of Results
Signal Processing, Computer-Assisted
Time Factors
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Zusammenfassung:It is well known that the quality of a quantitative 31P MRS measurement relies largely on the performance of the volume selection method, and that image selected in vivo spectroscopy (ISIS) suffers from contaminating signal caused mostly by T1 smearing. However, these signal errors and their magnitude are seldom addressed in clinical studies. The aim of this study was therefore to investigate the magnitude of signal errors in 31P MRS when using ISIS. The results from the measurements with a homogeneous head phantom are as follows: at low TR/T1 ratios the contamination increases rapidly, especially for small (
ISSN:0968-5243
1352-8661
DOI:10.1016/S1352-8661(01)00154-5