ETHANOL-REINFORCED BEHAVIOUR PREDICTS ACQUISITION BUT NOT EXTINCTION OF COCAINE SELF-ADMINISTRATION IN THE RAT
Aims: The aim of the present study was to evaluate the relationship between operant oral ethanol self-administration and intravenous (i.v.) cocaine self-administration in male Wistar rats. Methods: Twenty-four rats were trained to lever press for 8% v/v ethanol in the sucrose-fading procedure. The s...
Gespeichert in:
| Veröffentlicht in: | Alcohol and alcoholism (Oxford) 2003-11, Vol.38 (6), p.543-549 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 549 |
|---|---|
| container_issue | 6 |
| container_start_page | 543 |
| container_title | Alcohol and alcoholism (Oxford) |
| container_volume | 38 |
| creator | Mierzejewski, Pawel Rogowski, Artur Stefanski, Roman Goldberg, Steven Kostowski, Wojciech Bienkowski, Przemyslaw |
| description | Aims: The aim of the present study was to evaluate the relationship between operant oral ethanol self-administration and intravenous (i.v.) cocaine self-administration in male Wistar rats. Methods: Twenty-four rats were trained to lever press for 8% v/v ethanol in the sucrose-fading procedure. The subjects with the highest (high ethanol responders [HER], n = 7) and lowest (low ethanol responders [LER], n = 7) ethanol intakes were selected for further experiments. After a wash-out period, during which i.v. catheters were implanted, the HER and LER were trained to nose-poke for cocaine infusions (0.33 mg/kg/infusion, a FR1 schedule) for nine daily sessions. Results: The HER emitted more ‘active’ nose-pokes and obtained more cocaine infusions during sessions 2–4. Drug-seeking behaviour in the absence of cocaine reinforcement was then assessed for three consecutive extinction sessions. No between-group differences were found in terms of extinction of cocaine seeking. Locomotor responses to a novel environment were also similar in both groups. Conclusions: The present results suggest that a propensity to self-administer ethanol predicts more rapid acquisition of cocaine self-administration behaviour but does not influence subsequent behaviour during extinction. |
| doi_str_mv | 10.1093/alcalc/agg114 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71402190</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17269138</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-52d7f650585fe87d0822408c881f8018b3fabc9c47a2b8ca83e9c64e4db9d4073</originalsourceid><addsrcrecordid>eNqF0c1v0zAYB2ALgVg3OHJFFhLcwvyZOMcsdYilkrA0hYqL5TjO1NGPEbfS-O8xa0UlLkiWLPt9_Fo_vQC8wegjRim9Nmsb1rW5u8OYPQMTzGIWUY7IczBBCeURYphdgEvv7xHCjBL8ElwERGnM8ARsZVtmVT2LGqmqom5yOYU3ssy-qnrRwC-NnKq8ncMsv12ouWpVXcGbRQuruoVy2aoqf7qqC5jXeaYqCedyVkTZ9LOq1LxtsqeyqmBbShhOr8CLway9e33ar8CikG1eRrP6k8qzWWQZZ_uIkz4ZYo644IMTSY8EIQwJKwQeBMKio4PpbGpZYkgnrBHUpTZmjvVd2rMQ-wp8OPZ9GHc_D87v9WblrVuvzdbtDl4nmCGCU_RfiBMSp5iKAN_9A-93h3EbQmicCoI5ZTyg6IjsuPN-dIN-GFcbM_7SGOk_49LHcenjuIJ_e2p66DauP-vTfAJ4fwLGh4fDaLZ25c-OExFSoPPHK793j3_rZvyh44QmXJfL7zpd3oYk-Tdd0N_MC6N5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198215345</pqid></control><display><type>article</type><title>ETHANOL-REINFORCED BEHAVIOUR PREDICTS ACQUISITION BUT NOT EXTINCTION OF COCAINE SELF-ADMINISTRATION IN THE RAT</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Mierzejewski, Pawel ; Rogowski, Artur ; Stefanski, Roman ; Goldberg, Steven ; Kostowski, Wojciech ; Bienkowski, Przemyslaw</creator><creatorcontrib>Mierzejewski, Pawel ; Rogowski, Artur ; Stefanski, Roman ; Goldberg, Steven ; Kostowski, Wojciech ; Bienkowski, Przemyslaw</creatorcontrib><description>Aims: The aim of the present study was to evaluate the relationship between operant oral ethanol self-administration and intravenous (i.v.) cocaine self-administration in male Wistar rats. Methods: Twenty-four rats were trained to lever press for 8% v/v ethanol in the sucrose-fading procedure. The subjects with the highest (high ethanol responders [HER], n = 7) and lowest (low ethanol responders [LER], n = 7) ethanol intakes were selected for further experiments. After a wash-out period, during which i.v. catheters were implanted, the HER and LER were trained to nose-poke for cocaine infusions (0.33 mg/kg/infusion, a FR1 schedule) for nine daily sessions. Results: The HER emitted more ‘active’ nose-pokes and obtained more cocaine infusions during sessions 2–4. Drug-seeking behaviour in the absence of cocaine reinforcement was then assessed for three consecutive extinction sessions. No between-group differences were found in terms of extinction of cocaine seeking. Locomotor responses to a novel environment were also similar in both groups. Conclusions: The present results suggest that a propensity to self-administer ethanol predicts more rapid acquisition of cocaine self-administration behaviour but does not influence subsequent behaviour during extinction.</description><identifier>ISSN: 0735-0414</identifier><identifier>ISSN: 1464-3502</identifier><identifier>EISSN: 1464-3502</identifier><identifier>DOI: 10.1093/alcalc/agg114</identifier><identifier>PMID: 14633641</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animal ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Cocaine - administration & dosage ; Ethanol - administration & dosage ; Extinction, Psychological - drug effects ; Fundamental and applied biological sciences. Psychology ; Injections, Intravenous ; Learning ; Learning. Memory ; Male ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Wistar ; Reinforcement (Psychology) ; Self Administration</subject><ispartof>Alcohol and alcoholism (Oxford), 2003-11, Vol.38 (6), p.543-549</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Nov 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-52d7f650585fe87d0822408c881f8018b3fabc9c47a2b8ca83e9c64e4db9d4073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15281900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14633641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mierzejewski, Pawel</creatorcontrib><creatorcontrib>Rogowski, Artur</creatorcontrib><creatorcontrib>Stefanski, Roman</creatorcontrib><creatorcontrib>Goldberg, Steven</creatorcontrib><creatorcontrib>Kostowski, Wojciech</creatorcontrib><creatorcontrib>Bienkowski, Przemyslaw</creatorcontrib><title>ETHANOL-REINFORCED BEHAVIOUR PREDICTS ACQUISITION BUT NOT EXTINCTION OF COCAINE SELF-ADMINISTRATION IN THE RAT</title><title>Alcohol and alcoholism (Oxford)</title><addtitle>Alcohol and Alcoholism</addtitle><description>Aims: The aim of the present study was to evaluate the relationship between operant oral ethanol self-administration and intravenous (i.v.) cocaine self-administration in male Wistar rats. Methods: Twenty-four rats were trained to lever press for 8% v/v ethanol in the sucrose-fading procedure. The subjects with the highest (high ethanol responders [HER], n = 7) and lowest (low ethanol responders [LER], n = 7) ethanol intakes were selected for further experiments. After a wash-out period, during which i.v. catheters were implanted, the HER and LER were trained to nose-poke for cocaine infusions (0.33 mg/kg/infusion, a FR1 schedule) for nine daily sessions. Results: The HER emitted more ‘active’ nose-pokes and obtained more cocaine infusions during sessions 2–4. Drug-seeking behaviour in the absence of cocaine reinforcement was then assessed for three consecutive extinction sessions. No between-group differences were found in terms of extinction of cocaine seeking. Locomotor responses to a novel environment were also similar in both groups. Conclusions: The present results suggest that a propensity to self-administer ethanol predicts more rapid acquisition of cocaine self-administration behaviour but does not influence subsequent behaviour during extinction.</description><subject>Animal</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cocaine - administration & dosage</subject><subject>Ethanol - administration & dosage</subject><subject>Extinction, Psychological - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intravenous</subject><subject>Learning</subject><subject>Learning. Memory</subject><subject>Male</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reinforcement (Psychology)</subject><subject>Self Administration</subject><issn>0735-0414</issn><issn>1464-3502</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1v0zAYB2ALgVg3OHJFFhLcwvyZOMcsdYilkrA0hYqL5TjO1NGPEbfS-O8xa0UlLkiWLPt9_Fo_vQC8wegjRim9Nmsb1rW5u8OYPQMTzGIWUY7IczBBCeURYphdgEvv7xHCjBL8ElwERGnM8ARsZVtmVT2LGqmqom5yOYU3ssy-qnrRwC-NnKq8ncMsv12ouWpVXcGbRQuruoVy2aoqf7qqC5jXeaYqCedyVkTZ9LOq1LxtsqeyqmBbShhOr8CLway9e33ar8CikG1eRrP6k8qzWWQZZ_uIkz4ZYo644IMTSY8EIQwJKwQeBMKio4PpbGpZYkgnrBHUpTZmjvVd2rMQ-wp8OPZ9GHc_D87v9WblrVuvzdbtDl4nmCGCU_RfiBMSp5iKAN_9A-93h3EbQmicCoI5ZTyg6IjsuPN-dIN-GFcbM_7SGOk_49LHcenjuIJ_e2p66DauP-vTfAJ4fwLGh4fDaLZ25c-OExFSoPPHK793j3_rZvyh44QmXJfL7zpd3oYk-Tdd0N_MC6N5</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Mierzejewski, Pawel</creator><creator>Rogowski, Artur</creator><creator>Stefanski, Roman</creator><creator>Goldberg, Steven</creator><creator>Kostowski, Wojciech</creator><creator>Bienkowski, Przemyslaw</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>ETHANOL-REINFORCED BEHAVIOUR PREDICTS ACQUISITION BUT NOT EXTINCTION OF COCAINE SELF-ADMINISTRATION IN THE RAT</title><author>Mierzejewski, Pawel ; Rogowski, Artur ; Stefanski, Roman ; Goldberg, Steven ; Kostowski, Wojciech ; Bienkowski, Przemyslaw</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-52d7f650585fe87d0822408c881f8018b3fabc9c47a2b8ca83e9c64e4db9d4073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animal</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cocaine - administration & dosage</topic><topic>Ethanol - administration & dosage</topic><topic>Extinction, Psychological - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intravenous</topic><topic>Learning</topic><topic>Learning. Memory</topic><topic>Male</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reinforcement (Psychology)</topic><topic>Self Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mierzejewski, Pawel</creatorcontrib><creatorcontrib>Rogowski, Artur</creatorcontrib><creatorcontrib>Stefanski, Roman</creatorcontrib><creatorcontrib>Goldberg, Steven</creatorcontrib><creatorcontrib>Kostowski, Wojciech</creatorcontrib><creatorcontrib>Bienkowski, Przemyslaw</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Alcohol and alcoholism (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mierzejewski, Pawel</au><au>Rogowski, Artur</au><au>Stefanski, Roman</au><au>Goldberg, Steven</au><au>Kostowski, Wojciech</au><au>Bienkowski, Przemyslaw</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ETHANOL-REINFORCED BEHAVIOUR PREDICTS ACQUISITION BUT NOT EXTINCTION OF COCAINE SELF-ADMINISTRATION IN THE RAT</atitle><jtitle>Alcohol and alcoholism (Oxford)</jtitle><addtitle>Alcohol and Alcoholism</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>38</volume><issue>6</issue><spage>543</spage><epage>549</epage><pages>543-549</pages><issn>0735-0414</issn><issn>1464-3502</issn><eissn>1464-3502</eissn><abstract>Aims: The aim of the present study was to evaluate the relationship between operant oral ethanol self-administration and intravenous (i.v.) cocaine self-administration in male Wistar rats. Methods: Twenty-four rats were trained to lever press for 8% v/v ethanol in the sucrose-fading procedure. The subjects with the highest (high ethanol responders [HER], n = 7) and lowest (low ethanol responders [LER], n = 7) ethanol intakes were selected for further experiments. After a wash-out period, during which i.v. catheters were implanted, the HER and LER were trained to nose-poke for cocaine infusions (0.33 mg/kg/infusion, a FR1 schedule) for nine daily sessions. Results: The HER emitted more ‘active’ nose-pokes and obtained more cocaine infusions during sessions 2–4. Drug-seeking behaviour in the absence of cocaine reinforcement was then assessed for three consecutive extinction sessions. No between-group differences were found in terms of extinction of cocaine seeking. Locomotor responses to a novel environment were also similar in both groups. Conclusions: The present results suggest that a propensity to self-administer ethanol predicts more rapid acquisition of cocaine self-administration behaviour but does not influence subsequent behaviour during extinction.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>14633641</pmid><doi>10.1093/alcalc/agg114</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-0414 |
| ispartof | Alcohol and alcoholism (Oxford), 2003-11, Vol.38 (6), p.543-549 |
| issn | 0735-0414 1464-3502 1464-3502 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71402190 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animal Animals Behavior, Animal - drug effects Biological and medical sciences Cocaine - administration & dosage Ethanol - administration & dosage Extinction, Psychological - drug effects Fundamental and applied biological sciences. Psychology Injections, Intravenous Learning Learning. Memory Male Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Reinforcement (Psychology) Self Administration |
| title | ETHANOL-REINFORCED BEHAVIOUR PREDICTS ACQUISITION BUT NOT EXTINCTION OF COCAINE SELF-ADMINISTRATION IN THE RAT |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T07%3A39%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=ETHANOL-REINFORCED%20BEHAVIOUR%20PREDICTS%20ACQUISITION%20BUT%20NOT%20EXTINCTION%20OF%20COCAINE%20SELF-ADMINISTRATION%20IN%20THE%20RAT&rft.jtitle=Alcohol%20and%20alcoholism%20(Oxford)&rft.au=Mierzejewski,%20Pawel&rft.date=2003-11-01&rft.volume=38&rft.issue=6&rft.spage=543&rft.epage=549&rft.pages=543-549&rft.issn=0735-0414&rft.eissn=1464-3502&rft_id=info:doi/10.1093/alcalc/agg114&rft_dat=%3Cproquest_cross%3E17269138%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=198215345&rft_id=info:pmid/14633641&rfr_iscdi=true |