ETHANOL-REINFORCED BEHAVIOUR PREDICTS ACQUISITION BUT NOT EXTINCTION OF COCAINE SELF-ADMINISTRATION IN THE RAT

Aims: The aim of the present study was to evaluate the relationship between operant oral ethanol self-administration and intravenous (i.v.) cocaine self-administration in male Wistar rats. Methods: Twenty-four rats were trained to lever press for 8% v/v ethanol in the sucrose-fading procedure. The subjects with the highest (high ethanol responders [HER], n = 7) and lowest (low ethanol responders [LER], n = 7) ethanol intakes were selected for further experiments. After a wash-out period, during which i.v. catheters were implanted, the HER and LER were trained to nose-poke for cocaine infusions (0.33 mg/kg/infusion, a FR1 schedule) for nine daily sessions. Results: The HER emitted more ‘active’ nose-pokes and obtained more cocaine infusions during sessions 2–4. Drug-seeking behaviour in the absence of cocaine reinforcement was then assessed for three consecutive extinction sessions. No between-group differences were found in terms of extinction of cocaine seeking. Locomotor responses to a novel environment were also similar in both groups. Conclusions: The present results suggest that a propensity to self-administer ethanol predicts more rapid acquisition of cocaine self-administration behaviour but does not influence subsequent behaviour during extinction.