Mesonephroid adenocarcinoma. Apropos of a new case and review of the literature

Mesonephric adenocarcinoma is a rare clinical entity, predominantly appearing in women, involved in great controversy about its histogenesis. Reported cases to date were not diagnosed in their initial stages and they were treated by radical surgery with poor results. We report the case of a 71-year-old male with previous diagnosis of nephrogenic adenoma two years before. After the diagnosis of mesonephric adenocarcinoma was established, patient underwent radical surgery despite its poor prognosis. Differential diagnosis between these tumors should be made with primary or metastatic adenocarcinoma and nephrogenic adenoma. We highlight the ongoing controversy in the literature in relation to malignant evolution of the nephrogenic adenoma as etiology of the rare mesonephric adenocarcinoma. In this case, previous finding of a nephrogenic adenoma would support that theory.