Encapsulation of deoxyribonucleic acid molecules in silica and hybrid organic-silica gels

Encapsulation of deoxyribonucleic acid molecules in silica and hybrid organic-silica gels

The encapsulation of small DNA molecules was attempted in pure silica and in hybrid polyvinyl alcohol-silica gels. The materials which were obtained were examined by nitrogen adsorption, and by 29Si and 31P NMR spectroscopy. The extraction of the DNA molecules from the gels was examined in a buffer...

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Veröffentlicht in:Journal of materials science. Materials in medicine 2001-01, Vol.12 (1), p.51-55
Hauptverfasser: Pierre, A, Bonnet, J, Vekris, A, Portier, J
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Biomedical materials
Deoxyribonucleic acid
DNA
Encapsulation
Gels
Magnetic resonance spectroscopy
Materials science
Molecular chains
NMR spectroscopy
Polyvinyl alcohol
Silica
Silica gel
Silicon dioxide
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Zusammenfassung:The encapsulation of small DNA molecules was attempted in pure silica and in hybrid polyvinyl alcohol-silica gels. The materials which were obtained were examined by nitrogen adsorption, and by 29Si and 31P NMR spectroscopy. The extraction of the DNA molecules from the gels was examined in a buffer aqueous solution as well as in an acidic medium. The results suggested that the DNA molecules remained trapped inside the gels due to a permanent bonding to the gel network.
ISSN:0957-4530
1573-4838
DOI:10.1023/A:1013857102461