Peroxisome proliferator-activated receptor γ coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion

Sympathetic inputs inhibit insulin secretion through alpha2-adrenergic receptors coupled with Gi protein. High adrenergic tonus generated by exposure of homeothermic animals to cold reduces insulin secretion. In this study we evaluate the participation of UCP-2 in cold-induced regulation of insulin...

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Veröffentlicht in:	Diabetologia 2003-11, Vol.46 (11), p.1522-1531
Hauptverfasser:	DE SOUZA, C. T, GASPARETTI, A. L, PEREIRA-DA-SILVA, M, ARAUJO, E. P, CARVALHEIRA, J. B, SAAD, M. J. A, BOSCHERO, A. C, CARNEIRO, E. M, VELLOSO, L. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acclimatization - physiology Animals Base Sequence Biological and medical sciences Blood Glucose - metabolism Cold Temperature Diabetes. Impaired glucose tolerance DNA Primers Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy Metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects In Vitro Techniques Injections, Intravenous Insulin - blood Insulin - metabolism Insulin - pharmacology Insulin Secretion Ion Channels Islets of Langerhans - innervation Islets of Langerhans - metabolism Islets of Langerhans - physiology Leptin - blood Medical sciences Membrane Transport Proteins - genetics Mitochondrial Proteins - genetics Oligonucleotides, Antisense - pharmacology Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Rats Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Uncoupling Protein 2 Vertebrates: nervous system and sense organs
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Zusammenfassung:	Sympathetic inputs inhibit insulin secretion through alpha2-adrenergic receptors coupled with Gi protein. High adrenergic tonus generated by exposure of homeothermic animals to cold reduces insulin secretion. In this study we evaluate the participation of UCP-2 in cold-induced regulation of insulin secretion. Static insulin secretion studies, western blotting and immunohistochemistry were used in this investigation. Exposure of rats to cold during 8 days promoted 60% ( n=15, p
ISSN:	0012-186X 1432-0428
DOI:	10.1007/s00125-003-1222-5