Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin

N-Acylated ornithine analogues of daptomycin were synthesized and tested for their antibacterial efficacy. N-Acylated ornithine analogues of daptomycin were synthesized and tested for their antibacterial efficacy.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-12, Vol.13 (23), p.4187-4191
Hauptverfasser:	Hill, Jason, Siedlecki, James, Parr, Ian, Morytko, Michael, Yu, Xiang, Zhang, Yanzhi, Silverman, Jared, Controneo, Nicole, Laganas, Valerie, Li, Tongchuan, Lai, Jan-Ji, Keith, Dennis, Shimer, George, Finn, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Daptomycin - analogs & derivatives Daptomycin - chemical synthesis Daptomycin - pharmacology Mice Microbial Sensitivity Tests Ornithine - analogs & derivatives Ornithine - chemical synthesis Ornithine - pharmacology Sepsis - drug therapy Staphylococcal Infections - drug therapy Staphylococcus aureus - pathogenicity
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Beschreibung
Zusammenfassung:	N-Acylated ornithine analogues of daptomycin were synthesized and tested for their antibacterial efficacy. N-Acylated ornithine analogues of daptomycin were synthesized and tested for their antibacterial efficacy.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2003.07.019