Crucial role of stromal cell-derived factor-1alpha in neointima formation after vascular injury in apolipoprotein E-deficient mice

Recent evidence indicates that stromal cell-derived factor-1alpha (SDF-1alpha) is expressed in human atherosclerotic plaques, whereas high plasma levels are clinically associated with stable coronary artery disease. Herein, we investigate the involvement of SDF-1alpha in neointimal formation after v...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-11, Vol.108 (20), p.2491-2497
Hauptverfasser:	Schober, Andreas, Knarren, Sandra, Lietz, Michael, Lin, Elisa A, Weber, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Angioplasty - adverse effects Animals Antibodies, Monoclonal - pharmacology Antigens, Ly - biosynthesis Apolipoproteins E - deficiency Apolipoproteins E - genetics Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Stenosis - etiology Carotid Stenosis - metabolism Carotid Stenosis - pathology Carotid Stenosis - therapy Cell Lineage Cell Separation Chemokine CXCL12 Chemokines, CXC - antagonists & inhibitors Chemokines, CXC - immunology Chemokines, CXC - metabolism Disease Progression Female Immunohistochemistry Male Membrane Proteins - biosynthesis Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular Stem Cell Transplantation Stem Cells - cytology Stem Cells - metabolism Tunica Intima - metabolism Tunica Intima - pathology
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Zusammenfassung:	Recent evidence indicates that stromal cell-derived factor-1alpha (SDF-1alpha) is expressed in human atherosclerotic plaques, whereas high plasma levels are clinically associated with stable coronary artery disease. Herein, we investigate the involvement of SDF-1alpha in neointimal formation after vascular injury. SDF-1alpha was detected by immunohistochemistry in carotid arteries of apolipoprotein E-deficient (apoE-/-) mice at various stages of neointima formation after wire-induced injury. Double immunofluorescence revealed that SDF-1alpha staining was mostly confined to smooth muscle cells (SMCs). Furthermore, SDF-1alpha plasma levels peaked 1 day after vascular injury. Treatment of apoE-/- mice after carotid injury with a neutralizing SDF-1alpha monoclonal antibody for 3 weeks reduced neointimal lesion area by 44% (n=5, P
ISSN:	0009-7322 1524-4539