Stimulation of endothelial nitric oxide synthase by proinsulin C-peptide

There is increasing evidence for biological functions of human C-peptide. Recently, we have described that proinsulin C-peptide increases nutritive capillary blood flow and restores erythrocyte deformability in type 1 diabetic patients, whereas it has no such effect in non-diabetic subjects. The aim...

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Veröffentlicht in:	Nitric oxide 2003-09, Vol.9 (2), p.95-102
Hauptverfasser:	Wallerath, Thomas, Kunt, Thomas, Forst, Thomas, Closs, Ellen I, Lehmann, Ralf, Flohr, Thomas, Gabriel, Matthias, Schäfer, Dirk, Göpfert, Andrea, Pfützner, Andreas, Beyer, Jürgen, Förstermann, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - chemistry Animals Blotting, Western C-peptide C-Peptide - pharmacology Ca 2+ influx Calcium - metabolism Cattle Cyclic GMP - biosynthesis Cyclic GMP - metabolism Endothelial Cells - drug effects Endothelial Cells - enzymology Endothelial Cells - metabolism Endothelial nitric oxide synthase Enzyme Inhibitors - pharmacology Fluorescent Dyes Humans Microscopy, Fluorescence Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Nitroarginine - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry RNA - genetics Xanthenes - chemistry
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