Identification of novel small-molecule Ulex europaeus I mimetics for targeted drug delivery

Lectin mimetics have been identified that may have potential application towards targeted drug delivery. Synthetic multivalent polygalloyl constructs effectively competed with Ulex europaeus agglutinin I (UEA1) for binding to intestinal Caco-2 cell membranes.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2003-11, Vol.11 (23), p.4991-4997
Hauptverfasser:	HAMASHIN, Christa, SPINDLER, Lisa, RUSSELL, Shannon, SCHINK, Amy, LAMBKIN, Imelda, O'MAHONY, Daniel, HOUGHTEN, Richard, PINILLA, Clemencia
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Caco-2 Cells Humans Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Miscellaneous Molecular Mimicry Pharmacology. Drug treatments Plant Lectins - chemistry Plant Lectins - pharmacology
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Beschreibung
Zusammenfassung:	Lectin mimetics have been identified that may have potential application towards targeted drug delivery. Synthetic multivalent polygalloyl constructs effectively competed with Ulex europaeus agglutinin I (UEA1) for binding to intestinal Caco-2 cell membranes.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2003.09.002