Electron microscope appearance of lepromatous footpads of nude mice [corrected]

Footpad lesions of 3 nude mice infected by Mycobacterium leprae were studied at 9, 12, and 14 months after inoculation with light and electron microscope. The lesions were somewhat similar to those found in nodules in polar lepromatous leprosy. Striated muscles rather than nerves were the preferred...

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Veröffentlicht in:	International journal of leprosy and other mycobacterial diseases 2003-09, Vol.71 (3), p.231-239
Hauptverfasser:	Job, Charles K, McCormick, Grgory T, Scollard, David M, Truman, Richard W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endothelium, Vascular - cytology Endothelium, Vascular - microbiology Endothelium, Vascular - ultrastructure Foot - microbiology Foot - pathology Leprosy, Lepromatous - microbiology Leprosy, Lepromatous - pathology Macrophages - microbiology Macrophages - ultrastructure Mice Mice, Nude Microscopy, Electron Muscle, Skeletal - microbiology Muscle, Skeletal - ultrastructure Mycobacterium leprae - pathogenicity Mycobacterium leprae - ultrastructure Schwann Cells - microbiology Schwann Cells - ultrastructure
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Zusammenfassung:	Footpad lesions of 3 nude mice infected by Mycobacterium leprae were studied at 9, 12, and 14 months after inoculation with light and electron microscope. The lesions were somewhat similar to those found in nodules in polar lepromatous leprosy. Striated muscles rather than nerves were the preferred site of the growth of M. leprae. Yet, M. leprae were identified in Schwann cells and endothelial cells, singly and in clumps. M. leprae filled macrophages, and free M. leprae were found in large numbers in the endoneurium without producing any significant demyelination.
ISSN:	0148-916X