Oxidative killing of microbes by neutrophils

Oxidative killing of microbes by neutrophils

Neutrophils and other phagocytic leukocytes contain a phagocyte NADPH oxidase enzyme that generates superoxide after cell activation. Reactive oxygen species derived from superoxide, together with proteases liberated from the granules, are used to kill ingested microbes. Dysfunction of the phagocyte...

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Veröffentlicht in:Microbes and infection 2003-11, Vol.5 (14), p.1307-1315
Hauptverfasser: Roos, Dirk, van Bruggen, Robin, Meischl, Christof
Format: Artikel
Sprache:eng
Schlagworte:
Blood Bactericidal Activity
Chronic granulomatous disease
Granulomatous Disease, Chronic - immunology
Granulomatous Disease, Chronic - physiopathology
Humans
Killing
Microbes
NADPH oxidase
NADPH Oxidases - metabolism
Neutrophils
Neutrophils - enzymology
Neutrophils - immunology
Oxidation-Reduction
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Beschreibung
Zusammenfassung:Neutrophils and other phagocytic leukocytes contain a phagocyte NADPH oxidase enzyme that generates superoxide after cell activation. Reactive oxygen species derived from superoxide, together with proteases liberated from the granules, are used to kill ingested microbes. Dysfunction of the phagocyte NADPH oxidase results in chronic granulomatous disease, with life-threatening infections.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2003.09.009