The Lectin-Binding Properties of Six Generations of Mannose-Functionalized Dendrimers

First- through sixth-generation PAMAM dendrimers have been functionalized with mannose residues. Characterization with MALDI-TOF MS and 1H NMR is reported. Different binding enhancements consistent with monovalent interaction, glycoside clustering, and multivalent binding are observed for different...

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Veröffentlicht in:Organic letters 2002-01, Vol.4 (1), p.7-10
Hauptverfasser: Woller, Eric K, Cloninger, Mary J
Format: Artikel
Sprache:eng
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Zusammenfassung:First- through sixth-generation PAMAM dendrimers have been functionalized with mannose residues. Characterization with MALDI-TOF MS and 1H NMR is reported. Different binding enhancements consistent with monovalent interaction, glycoside clustering, and multivalent binding are observed for different generations of dendrimers.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol016568+