The Lectin-Binding Properties of Six Generations of Mannose-Functionalized Dendrimers
First- through sixth-generation PAMAM dendrimers have been functionalized with mannose residues. Characterization with MALDI-TOF MS and 1H NMR is reported. Different binding enhancements consistent with monovalent interaction, glycoside clustering, and multivalent binding are observed for different...
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Veröffentlicht in: | Organic letters 2002-01, Vol.4 (1), p.7-10 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | First- through sixth-generation PAMAM dendrimers have been functionalized with mannose residues. Characterization with MALDI-TOF MS and 1H NMR is reported. Different binding enhancements consistent with monovalent interaction, glycoside clustering, and multivalent binding are observed for different generations of dendrimers. |
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ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/ol016568+ |