Effect of channel geometry on the electrostatic potential in acetylcholine channels

We study the effect of channel geometry on the potential barrier encountered by ions as they permeate the acetylcholine receptor channel. Among the various channel geometries which have been used to represent the acetylcholine receptor channel include the cylinder and the toroidal catenary. The main...

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Veröffentlicht in:	Mathematical biosciences 2003-12, Vol.186 (2), p.175-189
1. Verfasser:	Aidoo, Anthony Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Hyperboloid Medical sciences Membrane Potentials - physiology Models, Chemical Neuromuscular junction Oblate spheroid Permeability Poisson Distribution Poisson equation Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Receptors, Cholinergic - chemistry Receptors, Cholinergic - physiology Static Electricity Technology. Biomaterials. Equipments. Material. Instrumentation
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Zusammenfassung:	We study the effect of channel geometry on the potential barrier encountered by ions as they permeate the acetylcholine receptor channel. Among the various channel geometries which have been used to represent the acetylcholine receptor channel include the cylinder and the toroidal catenary. The main reasons for those choices appear to be the facilitation of separation of the Poisson equation, rather than biological considerations. We consider a novel and realistic acetylcholine channel geometry, and calculate the electrostatic potential profiles within it, and compare our results with results from other channel geometries.
ISSN:	0025-5564 1879-3134
DOI:	10.1016/j.mbs.2003.08.008