Oxidative behaviour of apomorphine and its metabolites

The metabolism of apomorphine is quite complex due to interactions with proteins and other tissue components that affect its pharmacokinetic profile. The electrochemical oxidation mechanism of apomorphine and of some synthesised apomorphine derivatives was studied. It was found to be related to the...

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Veröffentlicht in:	Bioelectrochemistry (Amsterdam, Netherlands) Netherlands), 2002, Vol.55 (1), p.113-114
Hauptverfasser:	Garrido, J.M.P.J, Delerue-Matos, C, Borges, M.F.M, Macedo, T.R.A, Oliveira-Brett, A.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apomorphine Apomorphine - chemistry Apomorphine - metabolism Electrochemistry Hydrogen-Ion Concentration Oxidation-Reduction Oxidative behaviour
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The metabolism of apomorphine is quite complex due to interactions with proteins and other tissue components that affect its pharmacokinetic profile. The electrochemical oxidation mechanism of apomorphine and of some synthesised apomorphine derivatives was studied. It was found to be related to the reaction of o-diphenol and tertiary amine groups and strongly dependent on pH.
ISSN:	1567-5394 1878-562X
DOI:	10.1016/S1567-5394(01)00169-4