Electrochemistry of chalcogen compounds: prediction of antioxidant activity

Synthesis and characterisation of organochalcogens has demonstrated a high correlation between their electrochemical oxidation potential on the glassy carbon electrode, their activity in bioassays and an unprecedented antioxidant activity in neuronal cell culture (EC50 approximately 20 nM) making el...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2001-12 (23), p.2490-2491
Hauptverfasser: Giles, G I, Tasker, K M, Johnson, R J, Jacob, C, Peers, C, Green, K N
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Sprache:eng
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Zusammenfassung:Synthesis and characterisation of organochalcogens has demonstrated a high correlation between their electrochemical oxidation potential on the glassy carbon electrode, their activity in bioassays and an unprecedented antioxidant activity in neuronal cell culture (EC50 approximately 20 nM) making electrochemical methodology a valuable tool in drug design for Alzheimer's and related diseases.
ISSN:1359-7345
DOI:10.1039/b107972g