Usefulness of lowering low-density lipoprotein cholesterol to <70 mg/dl and usefulness of C-reactive protein in patient selection

Usefulness of lowering low-density lipoprotein cholesterol to <70 mg/dl and usefulness of C-reactive protein in patient selection

C-reactive protein levels may identify patients likely to benefit from lowering low-density lipoprotein (LDL) cholesterol to ultra-low levels. We find that above-average C-reactive protein with statin therapy predicts failure of carotid intima-media thickness regression in those with currently defin...

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Veröffentlicht in:The American journal of cardiology 2003-11, Vol.92 (10), p.1224-1227
Hauptverfasser: Kent, Steven M, Taylor, Allen J
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Atorvastatin
Biological and medical sciences
C-Reactive Protein - metabolism
Carotid Arteries - drug effects
Carotid Artery Diseases - blood
Carotid Artery Diseases - drug therapy
Cholesterol, LDL - blood
Female
General and cellular metabolism. Vitamins
Heptanoic Acids - therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Male
Medical sciences
Middle Aged
Patient Selection
Pharmacology. Drug treatments
Pravastatin - therapeutic use
Pyrroles - therapeutic use
Tunica Intima - drug effects
Tunica Media - drug effects
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Zusammenfassung:C-reactive protein levels may identify patients likely to benefit from lowering low-density lipoprotein (LDL) cholesterol to ultra-low levels. We find that above-average C-reactive protein with statin therapy predicts failure of carotid intima-media thickness regression in those with currently defined optimal LDL cholesterol (
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2003.07.040