A keaper and a striker maintain epidermal homeostasis

The actin-associated kelch-domain protein Keap1 acts upstream of the transcription factor Nrf2. Upon stress, Keap1 releases Nrf2 to activate the transcription of target genes. A new study now shows that these targets include keratins and cornified envelope proteins, possibly explaining why certain k...

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Veröffentlicht in:	Nature genetics 2003-11, Vol.35 (3), p.202-204
1. Verfasser:	Magin, Thomas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Agriculture Animal Genetics and Genomics Animals Biomedical and Life Sciences Biomedicine Cancer Research Carrier Proteins - physiology Complications and side effects Cytoskeletal Proteins DNA binding proteins DNA-Binding Proteins - physiology Epidermis - physiology Gene expression Gene Function Homeostasis - physiology Human Genetics Kelch-Like ECH-Associated Protein 1 Mice news-and-views NF-E2-Related Factor 2 Oxidative stress Physiological aspects Trans-Activators - physiology
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Beschreibung
Zusammenfassung:	The actin-associated kelch-domain protein Keap1 acts upstream of the transcription factor Nrf2. Upon stress, Keap1 releases Nrf2 to activate the transcription of target genes. A new study now shows that these targets include keratins and cornified envelope proteins, possibly explaining why certain keratin mutations predispose to chemical injury. The Keap1-Nrf2 partnership offers a mechanistic explanation for the response of tissues to mechanical and chemical injury.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng1103-202