Synthesis of new pryridyl alcohols and their use as catalysts in the asymmetric addition of diethylzinc to aldehydes

Synthesis of new pryridyl alcohols and their use as catalysts in the asymmetric addition of diethylzinc to aldehydes

Optically active new pyridyl alcohols 1–4, which can be easily synthesized by the reaction of (+)‐camphor or (−)‐menthone with lithiated pyridine derivatives, were applied as chiral ligands in the asymmetric addition of diethylzinc to aldehydes. Good yields with up to 94.0%enantiomeric excesses were...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chirality (New York, N.Y.) N.Y.), 2002, Vol.14 (1), p.28-31
Hauptverfasser: Xu, Qianyong, Wu, Xiaoming, Pan, Xinfu, Chan, Albert S. C., Yang, Teng-Kuei
Format: Artikel
Sprache:eng
Schlagworte:
(+)-camphor
(−)-menthone
asymmetric addition
diethylzinc
pyridyl alcohols
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Optically active new pyridyl alcohols 1–4, which can be easily synthesized by the reaction of (+)‐camphor or (−)‐menthone with lithiated pyridine derivatives, were applied as chiral ligands in the asymmetric addition of diethylzinc to aldehydes. Good yields with up to 94.0%enantiomeric excesses were observed in these reactions. Chirality 14:28–31, 2002. ©2002 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.10027