Synthesis of N-Alkylated derivatives of imidazole as antibacterial agents

N-Alkylation of imidazole, 2-methylimidazole and 2-methyl-4-nitroimidazole have been carried out to achieve effective antibacterial agents. The products were then investigated for antibacterial activity against Escherichia coil, Staphylococcus aureus and Pseudomonas aeruginosa. Antibacterial effects of 1-alkylimidazole derivatives increase as the number of carbons in alkyl chain increases up to nine carbons. Also substitution of 2-methyl and 2-methyl-4-nitro groups on imidazole ring increases the antibacterial activity. Alkylated derivatives of imidazole have been synthesized as antibacterial agents. Antibacterial effects of 1-alkylimidazole derivatives increase as the number of carbons in alkyl chain increase up to nine carbons. Also substitution of 2-methyl and 2-methyl-4-nitro groups on imidazole ring increase the antibacterial activity.