Uptake of Cadmium in Meals from the Digestive Tract of Young Non-smoking Japanese Female Volunteers

Uptake of Cadmium in Meals from the Digestive Tract of Young Non-smoking Japanese Female Volunteers: Yuriko KIKUCHl, et al. Department of Preventive Medicine and Public Health, School of Medicine. Keio University-Objectives-To estimate rates of cadmium (Cd) uptake from the digestive tract and changes in Cd in biological specimens after intake of Cd mainly in rice. Methods-Twenty-five young non-smoking Japanese female volunteers (20-23 in age) were recruited and a 20-d experimental study was conducted. With polished rice containing 0. 004 ppm and 0. 340 ppm of Cd, Meal L and Meal H were prepared. Approximately 12％ of total Cd in Meal L and 92％ of total Cd in Meal H originated in rice. The volunteers ate Meal L for 11 d to achieve a stable intake-output balance of Cd. Fifteen of the 25 volunteers ate Meal H on the 12th day (Group D1 ), and the remaining 10 ate Meal H on the 12th, 13th and 14th day (Group D3). All 25 subjects then resumed the consumption of Meal L to the end of the study (20th day). All meals, feces and urine were collected during the study, and Cd intake from the daily meals (Cd-1), Cd in feces (Cd-F) and Cd in urine (Cd-U) were determined. For measurement of Cd in blood (Cd-B), venous blood was collected from all volunteers on the day before the study and again on the 12th and 20*h day; venous blood was also collected from 4-8 volunteers at additional time points. Results-Mean Cd-1 was 4. 51 ktg/d (range: 1. 85-6. 93) or 48. 48 , 1gld (range: 27. 98-56. 27) when they ate Meal L or Meal H. Cd-F and Cd-B exhibited faster responses to the change in Cd-1 than did Cd-U. The Cd uptak. rate, defined