The Anti-HBsAg (Human Type B Hepatitis, Surface Antigen) and Anti-HBeAg (Human Type B Hepatitis, e Antigen) C18 Dibenzocyclooctadiene Lignans from Kadsura matsudai and Schizandra arisanensis

The C18 dibenzocyclooctadiene lignans including three novel schizanrin F (1), G (2), H (3), along with the known kadsurarin (4), were isolated from Kadsura matsudai. A new C19 homolignan named schiarisanrin E (5), together with the known C18 lignans, gomisin B (6), G (7) and (+)-gomisin K3 (8) were...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 2003, Vol.51(11), pp.1233-1236
Hauptverfasser: Wu, Ming-Der, Huang, Ray-Ling, Kuo, Li-Ming Yang, Hung, Chia-Cheng, Ong, Chi-Wi, Kuo, Yao-Haur
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Sprache:eng
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Zusammenfassung:The C18 dibenzocyclooctadiene lignans including three novel schizanrin F (1), G (2), H (3), along with the known kadsurarin (4), were isolated from Kadsura matsudai. A new C19 homolignan named schiarisanrin E (5), together with the known C18 lignans, gomisin B (6), G (7) and (+)-gomisin K3 (8) were obtained from Schizandra arisanensis. Gomisin B, G and (+)-gomisin K3 showed moderate to strong activity for antihepatitis in anti-HBsAg (human type B hepatitis, surface antigen) and/or anti-HBeAg (human type B hepatitis, e antigen) tests. The structural elucidations of new compounds 1—3 and 5 were based on two-dimensional (2D) NMR techniques including COSY, HMQC, HMBC, NOESY and CD spectra. Preliminary structure–activity relationship studies for these isolated lignans are also discussed.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.51.1233