Reduced collagenolytic activity of matrix metalloproteinases and development of liver fibrosis in the aging rat

Although moderate fibrosis is a histological hallmark of the aging liver, the molecular mechanisms underlying this phenomenon are little known. Here, we provide a comprehensive description of hepatic collagen expression and metabolism during natural aging in rats. Interstitial collagen accumulated s...

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Veröffentlicht in:	Mechanisms of ageing and development 2002-02, Vol.123 (4), p.413-425
Hauptverfasser:	Gagliano, Nicoletta, Arosio, Beatrice, Grizzi, Fabio, Masson, Serge, Tagliabue, Jacopo, Dioguardi, Nicola, Vergani, Carlo, Annoni, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Animals Biological and medical sciences Collagen Type I - genetics Collagen Type I - metabolism Collagen Type III - genetics Collagen Type III - metabolism Fibrosis Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Hydroxyproline - metabolism Liver Liver - metabolism Liver - pathology Liver Cirrhosis - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 2 - metabolism Matrix metalloproteinases Medical sciences Organ Size Other diseases. Semiology Rats Rats, Sprague-Dawley Tissue Inhibitor of Metalloproteinase-1 - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta1
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Zusammenfassung:	Although moderate fibrosis is a histological hallmark of the aging liver, the molecular mechanisms underlying this phenomenon are little known. Here, we provide a comprehensive description of hepatic collagen expression and metabolism during natural aging in rats. Interstitial collagen accumulated significantly in the oldest animals, mainly in the periportal area ( P
ISSN:	0047-6374 1872-6216
DOI:	10.1016/S0047-6374(01)00398-0