Solid-Phase Total Synthesis of Scytalidamide A

Solid-Phase Total Synthesis of Scytalidamide A

The first total synthesis of the natural cyclic heptapeptide scytalidamide A was achieved on solid phase using two different resins, a phenylalanine silane resin and a 4-methoxybenzaldehyde backbone linker resin. The synthetic product confirms the structure of the natural product reported in the pre...

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Veröffentlicht in:Journal of organic chemistry 2003-11, Vol.68 (23), p.8774-8779
Hauptverfasser: Gu, Wenxin, Silverman, Richard B
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Exact sciences and technology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Organic chemistry
Peptides
Peptides, Cyclic - chemical synthesis
Peptides, Cyclic - chemistry
Preparations and properties
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Zusammenfassung:The first total synthesis of the natural cyclic heptapeptide scytalidamide A was achieved on solid phase using two different resins, a phenylalanine silane resin and a 4-methoxybenzaldehyde backbone linker resin. The synthetic product confirms the structure of the natural product reported in the preceding paper in this issue (Tan, L. T.; Cheng, X. C.; Jensen, P. R.; Fenical, W. J. Org. Chem. 2003, 68, 8767).
ISSN:0022-3263
1520-6904
DOI:10.1021/jo0346712