A comparison of the effects of two continuous HRT regimens on cardiovascular risk factors

A comparison of the effects of two continuous HRT regimens on cardiovascular risk factors

In a study comparing the effects of two continuous HRT regimens on cardiovascular risk markers, 43 postmenopausal women were randomly assigned to receive either tibolone 2.5 mg/day ( n=20) or 0.625 mg/day conjugated equine oestrogens plus continuous medroxyprogesterone acetate 5 mg/day ( n=23). Seru...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Atherosclerosis 2002, Vol.160 (1), p.185-193
Hauptverfasser: Barnes, Judith F., Farish, Elizabeth, Rankin, Marion, Hart, David M.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Biomarkers - blood
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cholesterol, HDL - blood
Cholesterol, HDL - drug effects
Cholesterol, LDL - blood
Cholesterol, LDL - drug effects
Cholesterol, VLDL - blood
Cholesterol, VLDL - drug effects
Estrogen Receptor Modulators - therapeutic use
Estrogen Replacement Therapy
Estrogens, Conjugated (USP) - therapeutic use
Female
Hormones. Endocrine system
Humans
LDL oxidation
LDL subfractions
Lipoproteins
Medical sciences
Medroxyprogesterone Acetate - therapeutic use
Middle Aged
Nitrate/nitrite
Nitrates - blood
Nitrites - blood
Norpregnenes - therapeutic use
Oestrogen/progestogen
Oxidation-Reduction - drug effects
Pharmacology. Drug treatments
Postmenopausal
Progesterone Congeners - therapeutic use
Risk Factors
Tibolone
Time Factors
Treatment Outcome
Triglycerides - blood
United Kingdom - epidemiology
Women's Health
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In a study comparing the effects of two continuous HRT regimens on cardiovascular risk markers, 43 postmenopausal women were randomly assigned to receive either tibolone 2.5 mg/day ( n=20) or 0.625 mg/day conjugated equine oestrogens plus continuous medroxyprogesterone acetate 5 mg/day ( n=23). Serum lipoprotein levels, including LDL and HDL subfractions, oxidisability of LDL and serum nitrate/nitrite levels were determined before and during 12 weeks of therapy. Tibolone significantly reduced triglycerides (17.1%, P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(01)00560-3