Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7)

Pseudomonas aeruginosa isolates from an outbreak in Canada were highly resistant to carbapenems and ceftazidime but not piperacillin. They produced a novel integron-associated metallo-beta-lactamase, designated IMP-7, with 91% identity to IMP-1. bla(IMP-7) was not detected with standard bla(IMP)-spe...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2002-01, Vol.46 (1), p.255-258
Hauptverfasser:	Gibb, Alan Patrick, Tribuddharat, Chanwit, Moore, Richard A, Louie, Thomas J, Krulicki, Wally, Livermore, David M, Palepou, Marie-France I, Woodford, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence beta-Lactam Resistance - genetics beta-Lactamases - genetics Canada - epidemiology Carbapenems - pharmacology Cross Infection - epidemiology Disease Outbreaks Humans Molecular Sequence Data Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - genetics Pseudomonas Infections - epidemiology Pseudomonas Infections - microbiology Sequence Homology, Amino Acid Spermidine - analogs & derivatives Spermidine - pharmacology
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Zusammenfassung:	Pseudomonas aeruginosa isolates from an outbreak in Canada were highly resistant to carbapenems and ceftazidime but not piperacillin. They produced a novel integron-associated metallo-beta-lactamase, designated IMP-7, with 91% identity to IMP-1. bla(IMP-7) was not detected with standard bla(IMP)-specific primers, owing to mismatches in the forward primer.
ISSN:	0066-4804
DOI:	10.1128/AAC.46.1.255-258.2002