Advances in the hereditary spastic paraplegias

Advances in the hereditary spastic paraplegias

This review summarizes advances in understanding the genetics of the hereditary spastic paraplegias (HSPs), a diverse group of inherited disorders in which the primary symptom is insidiously progressive difficulty walking due to lower extremity spastic weakness. Twenty HSP loci and nine HSP genes ha...

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Veröffentlicht in:Experimental neurology 2003-11, Vol.184, p.106-110
1. Verfasser: Fink, John K
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chromosome Mapping
Genes, Dominant
Genetic Linkage
Humans
Lower Extremity
Sex Chromosome Aberrations
Spastic Paraplegia, Hereditary - classification
Spastic Paraplegia, Hereditary - diagnosis
Spastic Paraplegia, Hereditary - genetics
Spastic Paraplegia, Hereditary - pathology
Therapeutics
Walking
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Beschreibung
Zusammenfassung:This review summarizes advances in understanding the genetics of the hereditary spastic paraplegias (HSPs), a diverse group of inherited disorders in which the primary symptom is insidiously progressive difficulty walking due to lower extremity spastic weakness. Twenty HSP loci and nine HSP genes have been discovered. This progress has yielded new insights into the diverse molecular pathogenesis that underlies these clinically similar disorders.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2003.08.005