11,12-Epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-α-Induced VCAM-1 expression

A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-α-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET. A series of 11,12-EET analogues were synthesized and compared using a hum...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-11, Vol.13 (22), p.4011-4014
Hauptverfasser:	Falck, J.R, Reddy, L.Manmohan, Reddy, Y.Krishna, Bondlela, Muralidhar, Krishna, U.Murali, Ji, Yu, Sun, Jianxin, Liao, James K
Format:	Artikel
Sprache:	eng
Schlagworte:	8,11,14-Eicosatrienoic Acid - analogs & derivatives 8,11,14-Eicosatrienoic Acid - chemical synthesis 8,11,14-Eicosatrienoic Acid - chemistry 8,11,14-Eicosatrienoic Acid - pharmacology Animals Binding Sites Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Humans Medical sciences Molecular Structure Pharmacology. Drug treatments Structure-Activity Relationship Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - pharmacology Vascular Cell Adhesion Molecule-1 - chemistry Vascular Cell Adhesion Molecule-1 - drug effects Vascular Cell Adhesion Molecule-1 - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-α-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET. A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-α-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2003.08.060