Chronic Administration of Adrenomedullin Attenuates Transition From Left Ventricular Hypertrophy to Heart Failure in Rats

ABSTRACT—Acute administration of adrenomedullin (AM) exerts beneficial hemodynamic, renal, and neurohormonal effects in heart failure (HF). However, chronic effects of AM administration on HF remain unknown. This study sought to examine the effect of chronic infusion of AM on progression of HF in ra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2003-11, Vol.42 (5), p.1034-1041
Hauptverfasser:	Nishikimi, Toshio, Yoshihara, Fumiki, Horinaka, Shigeo, Kobayashi, Naohiko, Mori, Yosuke, Tadokoro, Kazuyoshi, Akimoto, Kazumi, Minamino, Naoto, Kangawa, Kenji, Matsuoka, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Animals Biological and medical sciences Blood Pressure - drug effects Cardiac Output - drug effects Cardiotonic agents Cardiovascular system Disease Progression Diuretics - therapeutic use Heart Failure - physiopathology Heart Failure - prevention & control Hemodynamics - drug effects Hypertrophy, Left Ventricular - drug therapy Hypertrophy, Left Ventricular - metabolism Hypertrophy, Left Ventricular - physiopathology Male Medical sciences Myocardium - metabolism Neurotransmitter Agents - blood Peptides - administration & dosage Peptides - therapeutic use Pharmacology. Drug treatments Rats Rats, Inbred Dahl Survival Rate Time Factors Vascular Resistance - drug effects Ventricular Pressure - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	ABSTRACT—Acute administration of adrenomedullin (AM) exerts beneficial hemodynamic, renal, and neurohormonal effects in heart failure (HF). However, chronic effects of AM administration on HF remain unknown. This study sought to examine the effect of chronic infusion of AM on progression of HF in rat. Human recombinant AM was administered by osmotic minipump for 7 weeks in the HF model of Dahl salt-sensitive rats. The effect was compared with vehicle and diuretic treatment group. Chronic AM infusion significantly decreased left ventricular end-diastolic pressure, right ventricular systolic pressure, right atrial pressure, and left ventricular weight/body weight (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.0000097604.64716.D2