Is high-grade adenomatous hyperplasia an early bronchioloalveolar adenocarcinoma?

Atypical adenomatous hyperplasia (AAH) is a probable forerunner of bronchioloalveolar carcinoma (BAC) and pulmonary adenocarcinoma (AC) of mixed type. The present study analysed four low‐grade AAHs, 13 high‐grade AAHs, two BACs, nine mixed ACs, and one squamous cell carcinoma derived from 13 patient...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of pathology 2003-11, Vol.201 (3), p.371-376
Hauptverfasser: Ullmann, R, Bongiovanni, M, Halbwedl, I, Fraire, AE, Cagle, PT, Mori, M, Papotti, M, Popper, Helmut H
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Atypical adenomatous hyperplasia (AAH) is a probable forerunner of bronchioloalveolar carcinoma (BAC) and pulmonary adenocarcinoma (AC) of mixed type. The present study analysed four low‐grade AAHs, 13 high‐grade AAHs, two BACs, nine mixed ACs, and one squamous cell carcinoma derived from 13 patients using comparative genomic hybridization. The average number of chromosomal aberrations was 1.2 in low‐grade AAH, 9.6 in high‐grade AAH, and 12.5 in AC. A high degree of overlap of genetic changes was found in high‐grade AAH, BAC, and AC within individual patients. The high number of aberrations and the degree of shared aberrations found in high‐grade AAH and AC raises questions about the separation of these two entities. In addition, in view of the monoclonal origin of multiple foci within the same patient, AAH may not be a precursor of AC in some cases, but rather may represent intraepithelial spread. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:0022-3417
1096-9896
DOI:10.1002/path.1460