13C-Labeled substrates and the cerebral metabolic compartmentalization of acetate and lactate

[1- 13C]Glucose, [2- 13C]acetate and [3- 13C]lactate were infused into male Sprague–Dawley rats (150–170 g) for periods of 3–100 min ( n=4 per time) and neocortex extracts were analyzed using 13C-edited 1H magnetic resonance (MR) spectroscopy. The time dependence of the [4- 13C]glutamine/[4- 13C]glu...

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Veröffentlicht in:	Brain research 2003-11, Vol.992 (1), p.43-52
Hauptverfasser:	Tyson, Randy Lee, Gallagher, Clare, Sutherland, Garnette Roy
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetate Acetates - administration & dosage Acetates - metabolism Animals Biochemistry and metabolism Biological and medical sciences Carbon Radioisotopes - metabolism Central nervous system Fundamental and applied biological sciences. Psychology Glucose Glucose - administration & dosage Glucose - metabolism Lactate Lactic Acid - administration & dosage Lactic Acid - metabolism Magnetic Resonance Spectroscopy Male Metabolism Neocortex - metabolism Neuroglia - metabolism Neurons - metabolism Nuclear magnetic resonance spectroscopy Rats Rats, Sprague-Dawley Time Factors Vertebrates: nervous system and sense organs
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Zusammenfassung:	[1- 13C]Glucose, [2- 13C]acetate and [3- 13C]lactate were infused into male Sprague–Dawley rats (150–170 g) for periods of 3–100 min ( n=4 per time) and neocortex extracts were analyzed using 13C-edited 1H magnetic resonance (MR) spectroscopy. The time dependence of the [4- 13C]glutamine/[4- 13C]glutamate labeling ratio was significantly different for all three substrates infused ( p
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2003.08.027