Familial Clustering of Intracerebral Hemorrhage: A Prospective Study in North Carolina

Few studies have assessed the frequency of familial clustering in intracerebral hemorrhage (ICH). Of 144 patients with ICH prospectively assessed, 14 (9.8%) had a positive family history of ICH (FH+). Four pedigrees had more than two affected family members. Comparisons between FH+ and FH– probands...

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Veröffentlicht in:	Neuroepidemiology 2002-01, Vol.21 (1), p.18-21
Hauptverfasser:	Alberts, M.J., McCarron, M.O., Hoffmann, K.L., Graffagnino, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Basal Ganglia Cerebrovascular Disease - epidemiology Basal Ganglia Cerebrovascular Disease - genetics Cerebral Hemorrhage - epidemiology Cerebral Hemorrhage - genetics Cluster Analysis Cross-Sectional Studies Female Genetic Predisposition to Disease - genetics Humans Male Middle Aged North Carolina Original Paper Pedigree Prospective Studies Risk Factors
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Zusammenfassung:	Few studies have assessed the frequency of familial clustering in intracerebral hemorrhage (ICH). Of 144 patients with ICH prospectively assessed, 14 (9.8%) had a positive family history of ICH (FH+). Four pedigrees had more than two affected family members. Comparisons between FH+ and FH– probands demonstrated no significant differences in race, age, sex, ICH type or location. An underlying genetic etiology may account for familial clustering in some ICH patients.
ISSN:	0251-5350 1423-0208
DOI:	10.1159/000048609