Brain flow changes before and after deep brain stimulation of the subthalamic nucleus in Parkinson's disease

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) markedly improves motor symptoms and reduces medication needs in Parkinson's disease (PD) patients. However, its effect on brain function has remained unclear. We used SPECT and the tracer ECD to measure regional cerebral blood flow...

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Veröffentlicht in:	Neurological sciences 2003-10, Vol.24 (3), p.151-152
Hauptverfasser:	Antonini, A, Marotta, G, Benti, R, Landi, A, De Notaris, R, Mariani, C, Gerundini, P, Pezzoli, G, Gaini, S M
Format:	Artikel
Sprache:	eng
Schlagworte:	Case-Control Studies Cerebrovascular Circulation Electric Stimulation - methods Electric Stimulation Therapy Follow-Up Studies Humans Magnetic Resonance Imaging - methods Neurology Neurosciences Parkinson Disease - diagnostic imaging Parkinson Disease - therapy Subthalamic Nucleus - diagnostic imaging Subthalamic Nucleus - physiopathology Time Factors Tomography, Emission-Computed, Single-Photon - methods
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Zusammenfassung:	Deep brain stimulation (DBS) of the subthalamic nucleus (STN) markedly improves motor symptoms and reduces medication needs in Parkinson's disease (PD) patients. However, its effect on brain function has remained unclear. We used SPECT and the tracer ECD to measure regional cerebral blood flow before and 6 months after DBS of the STN in 22 PD patients and 13 healthy controls. PD patients were divided into good and poor responders to DBS, if changes in "off" UPDRS motor scores after surgery were >60% or
ISSN:	1590-1874 1590-3478
DOI:	10.1007/s10072-003-0104-4