Technology and physico-chemical evaluation of solid ocular inserts containing sulfadicramide and hyaluronic acid

Technology and physico-chemical evaluation of solid ocular inserts containing sulfadicramide and hyaluronic acid

Synthetic lipophilic membranes, containing sulfadicramide (SDC), disodium salt of hyaluronic acid and disodium salt of taurolithocholic acid were prepared as described (Fürst et al.). Rate constants of SDC release from the above membranes and its apparent permeability coefficients through the comea...

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Veröffentlicht in:Acta Poloniae pharmaceutica 2001-11, Vol.58 (6), p.453-458
Hauptverfasser: Grześkowiak, E, Partyka, D, Simon, M, Zgrabczyńska, M, Wiśniewska, A
Format: Artikel
Sprache:eng
Schlagworte:
Amides - pharmacokinetics
Animals
Chemical Phenomena
Chemistry, Physical
Cornea - metabolism
Drug Evaluation, Preclinical - methods
Hyaluronic Acid - pharmacokinetics
Membranes, Artificial
Swine
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Zusammenfassung:Synthetic lipophilic membranes, containing sulfadicramide (SDC), disodium salt of hyaluronic acid and disodium salt of taurolithocholic acid were prepared as described (Fürst et al.). Rate constants of SDC release from the above membranes and its apparent permeability coefficients through the comea isolated from the pig's eyes were determined.
ISSN:0001-6837