Preload induces troponin I degradation independently of myocardial ischemia

Although global ischemia induces troponin I (TnI) degradation, regional ischemia does not. We hypothesized that this disparity is related to preload-induced proteolysis, which varies as a function of the amount of myocardium at risk of ischemia. Isolated rat hearts were buffer-perfused at controlled...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2001-04, Vol.103 (16), p.2035-2037
Hauptverfasser:	JUN FENG, SCHAUS, Benjamin J, FALLAVOLLITA, James A, LEE, Te-Chung, CANTY, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure Calpain - antagonists & inhibitors Calpain - metabolism Cardiac Pacing, Artificial Cardiology. Vascular system Coronary heart disease Cysteine Proteinase Inhibitors - pharmacology Dipeptides - pharmacology Heart Heart - drug effects Heart - physiology Heart - physiopathology Hemodynamics In Vitro Techniques Medical sciences Myocardial Ischemia - metabolism Myocardium - metabolism Rats Rats, Sprague-Dawley Troponin I - metabolism Ventricular Function, Left - drug effects
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