Preload induces troponin I degradation independently of myocardial ischemia

Preload induces troponin I degradation independently of myocardial ischemia

Although global ischemia induces troponin I (TnI) degradation, regional ischemia does not. We hypothesized that this disparity is related to preload-induced proteolysis, which varies as a function of the amount of myocardium at risk of ischemia. Isolated rat hearts were buffer-perfused at controlled...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 2001-04, Vol.103 (16), p.2035-2037
Hauptverfasser: JUN FENG, SCHAUS, Benjamin J, FALLAVOLLITA, James A, LEE, Te-Chung, CANTY, John M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Blood Pressure
Calpain - antagonists & inhibitors
Calpain - metabolism
Cardiac Pacing, Artificial
Cardiology. Vascular system
Coronary heart disease
Cysteine Proteinase Inhibitors - pharmacology
Dipeptides - pharmacology
Heart
Heart - drug effects
Heart - physiology
Heart - physiopathology
Hemodynamics
In Vitro Techniques
Medical sciences
Myocardial Ischemia - metabolism
Myocardium - metabolism
Rats
Rats, Sprague-Dawley
Troponin I - metabolism
Ventricular Function, Left - drug effects
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Zusammenfassung:Although global ischemia induces troponin I (TnI) degradation, regional ischemia does not. We hypothesized that this disparity is related to preload-induced proteolysis, which varies as a function of the amount of myocardium at risk of ischemia. Isolated rat hearts were buffer-perfused at controlled levels of preload. Increasing preload to 25 mm Hg in the absence of ischemia produced pronounced TnI degradation (27 kDa versus 31 kDa bands: 16.4 +/- 3.6% versus 4.7 +/- 1.9% in immediately excised controls, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.103.16.2035