Development of a Novel Sugar Linkage: 6,6′-Ether-Connected Sugars

Development of a Novel Sugar Linkage: 6,6′-Ether-Connected Sugars

Unusual sugar dimers: The synthesis of 6,6′‐ether‐connected pyranoses by an acetalization–reduction procedure is described (see scheme). Structure–activity‐relationship studies of these novel carbohydrate dimers suggested that the natural product coyolosa, which has been shown to have a significant...

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Veröffentlicht in:Angewandte Chemie International Edition 2003-10, Vol.42 (41), p.5069-5071
Hauptverfasser: Takahashi, Hideyo, Fukuda, Toshimitsu, Mitsuzuka, Haruhiko, Namme, Rie, Miyamoto, Hidetoshi, Ohkura, Yasufumi, Ikegami, Shiro
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Sprache:eng
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antidiabetic agents
carbohydrates
ethers
structure-activity relationships
synthetic methods
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container_end_page 5071
container_issue 41
container_start_page 5069
container_title Angewandte Chemie International Edition
container_volume 42
creator Takahashi, Hideyo
Fukuda, Toshimitsu
Mitsuzuka, Haruhiko
Namme, Rie
Miyamoto, Hidetoshi
Ohkura, Yasufumi
Ikegami, Shiro
description Unusual sugar dimers: The synthesis of 6,6′‐ether‐connected pyranoses by an acetalization–reduction procedure is described (see scheme). Structure–activity‐relationship studies of these novel carbohydrate dimers suggested that the natural product coyolosa, which has been shown to have a significant effect on fasting blood‐glucose levels, may have a different structure from the one previously reported.
doi_str_mv 10.1002/anie.200352388
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source Wiley Online Library Journals Frontfile Complete
subjects antidiabetic agents
carbohydrates
ethers
structure-activity relationships
synthetic methods
title Development of a Novel Sugar Linkage: 6,6′-Ether-Connected Sugars
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