Development of a Novel Sugar Linkage: 6,6′-Ether-Connected Sugars

Development of a Novel Sugar Linkage: 6,6′-Ether-Connected Sugars

Unusual sugar dimers: The synthesis of 6,6′‐ether‐connected pyranoses by an acetalization–reduction procedure is described (see scheme). Structure–activity‐relationship studies of these novel carbohydrate dimers suggested that the natural product coyolosa, which has been shown to have a significant...

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Veröffentlicht in:Angewandte Chemie International Edition 2003-10, Vol.42 (41), p.5069-5071
Hauptverfasser: Takahashi, Hideyo, Fukuda, Toshimitsu, Mitsuzuka, Haruhiko, Namme, Rie, Miyamoto, Hidetoshi, Ohkura, Yasufumi, Ikegami, Shiro
Format: Artikel
Sprache:eng
Schlagworte:
antidiabetic agents
carbohydrates
ethers
structure-activity relationships
synthetic methods
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Zusammenfassung:Unusual sugar dimers: The synthesis of 6,6′‐ether‐connected pyranoses by an acetalization–reduction procedure is described (see scheme). Structure–activity‐relationship studies of these novel carbohydrate dimers suggested that the natural product coyolosa, which has been shown to have a significant effect on fasting blood‐glucose levels, may have a different structure from the one previously reported.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200352388