Enantioselective deprotonation reactions using polymer-supported chiral magnesium amide bases

Enantioselective deprotonation reactions using polymer-supported chiral magnesium amide bases

Novel and readily accessible polymer-supported chiral magnesium amide reagents have been prepared and shown to be effective in the asymmetric deprotonation of a series of prochiral cyclohexanones, affording good to excellent levels of both conversion and enantiomeric ratio (up to 93:7); the Merrifie...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2001 (18), p.1722-1723
Hauptverfasser: Henderson, K W, Kerr, W J, Moir, J H
Format: Artikel
Sprache:eng
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Zusammenfassung:Novel and readily accessible polymer-supported chiral magnesium amide reagents have been prepared and shown to be effective in the asymmetric deprotonation of a series of prochiral cyclohexanones, affording good to excellent levels of both conversion and enantiomeric ratio (up to 93:7); the Merrifield-based chiral amine species has been shown to be readily recyclable.
ISSN:1359-7345
1364-548X
DOI:10.1039/b104417f