A novel sunscreen agent having antimelanoma activity

A novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62...

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Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 2003-11, Vol.58 (11), p.1163-1169
Hauptverfasser:	Nogueira, Marisa A, Magalhães, Eva G, Magalhães, Aderbal F, Biloti, Débora N, Laverde, Antonio, Pessine, Francisco B.T, Carvalho, João E, Kohn, Luciana K, Antônio, Márcia A, Marsaioli, Anita J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Applied sciences Benzoates - chemistry Benzoates - therapeutic use Biological and medical sciences Cancer Cell Line, Tumor Chalcones Chemical industry and chemicals Cosmetics, toiletries Dibenzoylmethane derivatives Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Exact sciences and technology General aspects Humans Medical sciences Melanoma Melanoma - drug therapy Melanoma - prevention & control Pharmacology. Drug treatments Skin Neoplasms - prevention & control Sunscreening Agents - chemistry Sunscreening Agents - therapeutic use UV sunscreen Washing products. Cosmetics and toiletries. Perfumes
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Zusammenfassung:	A novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62 (melanoma)) were used for the cytotoxic assay. Eight among the 19 dibenzoylmethane derivatives showed cytotoxicity against these four cell lines. Absorption spectroscopies revealed that these compounds can be used as sunscreens against UV radiation.
ISSN:	0014-827X 1879-0569
DOI:	10.1016/S0014-827X(03)00195-2