Diastereoselectivity controlled by electrostatic repulsion between the negative charge on a trifluoromethyl group and that on aromatic rings

Diastereoselectivity controlled by electrostatic repulsion between the negative charge on a trifluoromethyl group and that on aromatic rings

Intramolecular electrostatic repulsions between the local negative charge on a trifluoromethyl group and that on the ortho position of an aryl moiety of a nucleophile was found to be a controlling factor of the diastereoselectivity in a cyclopropanation reaction, in which the electrostatic repulsion...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2001-10 (20), p.2054-2055
Hauptverfasser: Katagiri, T, Yamaji, S, Handa, M, Irie, M, Uneyama, K
Format: Artikel
Sprache:eng
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Zusammenfassung:Intramolecular electrostatic repulsions between the local negative charge on a trifluoromethyl group and that on the ortho position of an aryl moiety of a nucleophile was found to be a controlling factor of the diastereoselectivity in a cyclopropanation reaction, in which the electrostatic repulsion was evaluated quantitatively.
ISSN:1359-7345
DOI:10.1039/b105602f