Risk factors for recent transmission of Mycobacterium tuberculosis
In recent decades, the decline of tuberculosis has stopped in Western Europe, mainly due to increased immigration from high-prevalence countries. The objective of the current study was to identify risk factors for developing tuberculosis following recent infection, in order to better target interven...
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| Veröffentlicht in: | The European respiratory journal 2003-10, Vol.22 (4), p.637-642 |
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| container_title | The European respiratory journal |
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| creator | Heldal, E Dahle, U.R Sandven, P Caugant, D.A Brattaas, N Waaler, H.T Enarson, D.A Tverdal, A Kongerud, J |
| description | In recent decades, the decline of tuberculosis has stopped in Western Europe, mainly due to increased immigration from high-prevalence countries. The objective of the current study was to identify risk factors for developing tuberculosis following recent infection, in order to better target interventions. Strains from 861 culture-positive cases, diagnosed in Norway in 1994-1999, were analysed by use of restriction fragment length polymorphism (RFLP). A cluster was defined as two or more isolates with identical RFLP patterns. Risk factors for being part of a cluster were identified by univariate and multivariate analysis. A total of 134 patients were part of a cluster. These constituted 5% Asian-born, 18% Norwegian-born, 24% European-born and 29% African-born patients. Four independent risk factors for being part of a cluster were identified: being born in Norway, being of young age, being infected with an isoniazid-resistant strain and being infected with a multidrug-resistant strain. Transmission of tuberculosis may be further reduced by improving case management, contact tracing, preventive treatment, screening of immigrants and access to health services for the foreign-born population. |
| doi_str_mv | 10.1183/09031936.03.00019103 |
| format | Article |
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The objective of the current study was to identify risk factors for developing tuberculosis following recent infection, in order to better target interventions. Strains from 861 culture-positive cases, diagnosed in Norway in 1994-1999, were analysed by use of restriction fragment length polymorphism (RFLP). A cluster was defined as two or more isolates with identical RFLP patterns. Risk factors for being part of a cluster were identified by univariate and multivariate analysis. A total of 134 patients were part of a cluster. These constituted 5% Asian-born, 18% Norwegian-born, 24% European-born and 29% African-born patients. Four independent risk factors for being part of a cluster were identified: being born in Norway, being of young age, being infected with an isoniazid-resistant strain and being infected with a multidrug-resistant strain. Transmission of tuberculosis may be further reduced by improving case management, contact tracing, preventive treatment, screening of immigrants and access to health services for the foreign-born population.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.03.00019103</identifier><identifier>PMID: 14582917</identifier><language>eng</language><publisher>Leeds: Eur Respiratory Soc</publisher><subject>Adolescent ; Adult ; Age Factors ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial diseases ; Biological and medical sciences ; Case-Control Studies ; Child ; Child, Preschool ; Cluster Analysis ; Drug Resistance, Multiple, Bacterial ; Female ; Human bacterial diseases ; Humans ; Incidence ; Infant ; Infectious diseases ; Male ; Medical sciences ; Mycobacterium tuberculosis - genetics ; Norway - epidemiology ; Pharmacology. Drug treatments ; Polymorphism, Restriction Fragment Length ; Residence Characteristics ; Risk Factors ; Time Factors ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Pulmonary - epidemiology ; Tuberculosis, Pulmonary - microbiology ; Tuberculosis, Pulmonary - transmission</subject><ispartof>The European respiratory journal, 2003-10, Vol.22 (4), p.637-642</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-577f4e33231d890e49d27c6a3bfae5b4ebd157da4f409f61de19316946cce3aa3</citedby><cites>FETCH-LOGICAL-c458t-577f4e33231d890e49d27c6a3bfae5b4ebd157da4f409f61de19316946cce3aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15155527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14582917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heldal, E</creatorcontrib><creatorcontrib>Dahle, U.R</creatorcontrib><creatorcontrib>Sandven, P</creatorcontrib><creatorcontrib>Caugant, D.A</creatorcontrib><creatorcontrib>Brattaas, N</creatorcontrib><creatorcontrib>Waaler, H.T</creatorcontrib><creatorcontrib>Enarson, D.A</creatorcontrib><creatorcontrib>Tverdal, A</creatorcontrib><creatorcontrib>Kongerud, J</creatorcontrib><title>Risk factors for recent transmission of Mycobacterium tuberculosis</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>In recent decades, the decline of tuberculosis has stopped in Western Europe, mainly due to increased immigration from high-prevalence countries. The objective of the current study was to identify risk factors for developing tuberculosis following recent infection, in order to better target interventions. Strains from 861 culture-positive cases, diagnosed in Norway in 1994-1999, were analysed by use of restriction fragment length polymorphism (RFLP). A cluster was defined as two or more isolates with identical RFLP patterns. Risk factors for being part of a cluster were identified by univariate and multivariate analysis. A total of 134 patients were part of a cluster. These constituted 5% Asian-born, 18% Norwegian-born, 24% European-born and 29% African-born patients. Four independent risk factors for being part of a cluster were identified: being born in Norway, being of young age, being infected with an isoniazid-resistant strain and being infected with a multidrug-resistant strain. Transmission of tuberculosis may be further reduced by improving case management, contact tracing, preventive treatment, screening of immigrants and access to health services for the foreign-born population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cluster Analysis</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Norway - epidemiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Residence Characteristics</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Pulmonary - epidemiology</subject><subject>Tuberculosis, Pulmonary - microbiology</subject><subject>Tuberculosis, Pulmonary - transmission</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0MFu1DAQBmALgei28AYI5UJvWTweJ1kfoWoLUlElBGfLccbUJVm3nkRV3x6vmqqcPIdvfo9-IT6A3ALs8LM0EsFgu5W4lVKCAYmvxAbQmBqlxNdicyD1wRyJY-bbglqN8FYcgW52ykC3EV9_Rv5bBefnlLkKKVeZPO3nas5uz1NkjmlfpVD9ePSpL4xyXKZqXnrKfhkTR34n3gQ3Mr1f3xPx--L819m3-ur68vvZl6val9_muum6oAlRIQw7I0mbQXW-ddgHR02vqR-g6Qang5YmtDBQuRxao1vvCZ3DE3H6lHuX0_1CPNtynqdxdHtKC9sOUCm10wXqJ-hzYs4U7F2Ok8uPFqQ9dGefu7OyzGt3Ze3jmr_0Ew0vS2tZBXxagWPvxlAa8pFfXANN06j_3E38c_MQM1me3DiWWLCUb5Wy2rbY4T9ZAIPg</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Heldal, E</creator><creator>Dahle, U.R</creator><creator>Sandven, P</creator><creator>Caugant, D.A</creator><creator>Brattaas, N</creator><creator>Waaler, H.T</creator><creator>Enarson, D.A</creator><creator>Tverdal, A</creator><creator>Kongerud, J</creator><general>Eur Respiratory Soc</general><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Risk factors for recent transmission of Mycobacterium tuberculosis</title><author>Heldal, E ; Dahle, U.R ; Sandven, P ; Caugant, D.A ; Brattaas, N ; Waaler, H.T ; Enarson, D.A ; Tverdal, A ; Kongerud, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-577f4e33231d890e49d27c6a3bfae5b4ebd157da4f409f61de19316946cce3aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cluster Analysis</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Norway - epidemiology</topic><topic>Pharmacology. 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The objective of the current study was to identify risk factors for developing tuberculosis following recent infection, in order to better target interventions. Strains from 861 culture-positive cases, diagnosed in Norway in 1994-1999, were analysed by use of restriction fragment length polymorphism (RFLP). A cluster was defined as two or more isolates with identical RFLP patterns. Risk factors for being part of a cluster were identified by univariate and multivariate analysis. A total of 134 patients were part of a cluster. These constituted 5% Asian-born, 18% Norwegian-born, 24% European-born and 29% African-born patients. Four independent risk factors for being part of a cluster were identified: being born in Norway, being of young age, being infected with an isoniazid-resistant strain and being infected with a multidrug-resistant strain. 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| subjects | Adolescent Adult Age Factors Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Biological and medical sciences Case-Control Studies Child Child, Preschool Cluster Analysis Drug Resistance, Multiple, Bacterial Female Human bacterial diseases Humans Incidence Infant Infectious diseases Male Medical sciences Mycobacterium tuberculosis - genetics Norway - epidemiology Pharmacology. Drug treatments Polymorphism, Restriction Fragment Length Residence Characteristics Risk Factors Time Factors Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - transmission |
| title | Risk factors for recent transmission of Mycobacterium tuberculosis |
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