Risk factors for recent transmission of Mycobacterium tuberculosis

In recent decades, the decline of tuberculosis has stopped in Western Europe, mainly due to increased immigration from high-prevalence countries. The objective of the current study was to identify risk factors for developing tuberculosis following recent infection, in order to better target interven...

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Veröffentlicht in:The European respiratory journal 2003-10, Vol.22 (4), p.637-642
Hauptverfasser: Heldal, E, Dahle, U.R, Sandven, P, Caugant, D.A, Brattaas, N, Waaler, H.T, Enarson, D.A, Tverdal, A, Kongerud, J
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Sprache:eng
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Zusammenfassung:In recent decades, the decline of tuberculosis has stopped in Western Europe, mainly due to increased immigration from high-prevalence countries. The objective of the current study was to identify risk factors for developing tuberculosis following recent infection, in order to better target interventions. Strains from 861 culture-positive cases, diagnosed in Norway in 1994-1999, were analysed by use of restriction fragment length polymorphism (RFLP). A cluster was defined as two or more isolates with identical RFLP patterns. Risk factors for being part of a cluster were identified by univariate and multivariate analysis. A total of 134 patients were part of a cluster. These constituted 5% Asian-born, 18% Norwegian-born, 24% European-born and 29% African-born patients. Four independent risk factors for being part of a cluster were identified: being born in Norway, being of young age, being infected with an isoniazid-resistant strain and being infected with a multidrug-resistant strain. Transmission of tuberculosis may be further reduced by improving case management, contact tracing, preventive treatment, screening of immigrants and access to health services for the foreign-born population.
ISSN:0903-1936
1399-3003
DOI:10.1183/09031936.03.00019103