Chromatid transport by pantographic motors (PMS)

Chromatid transport by pantographic motors (PMS)

The paper discusses a system of hinged leverages functioning as (vectorial) pantographic motors (PMs). Mediated by ratchets, PMs are suited for ferrying mammalian chromatids to mitotic antipoles. Several self-rectifying modes allow PMs to accurately partition genomes with minimal risk of engendering...

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Veröffentlicht in:Medical hypotheses 2003-11, Vol.61 (5), p.636-639
1. Verfasser: Matioli, G.T
Format: Artikel
Sprache:eng
Schlagworte:
Aneuploidy
Animals
Biological Transport, Active
Chromatids - metabolism
Chromatids - physiology
Humans
Ions
Kinetochores - metabolism
Mitosis
Models, Theoretical
Molecular Motor Proteins
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Beschreibung
Zusammenfassung:The paper discusses a system of hinged leverages functioning as (vectorial) pantographic motors (PMs). Mediated by ratchets, PMs are suited for ferrying mammalian chromatids to mitotic antipoles. Several self-rectifying modes allow PMs to accurately partition genomes with minimal risk of engendering aneuploidy.
ISSN:0306-9877
1532-2777
DOI:10.1016/S0306-9877(03)00254-8