A Role for Rab7 GTPase in Growth Factor-Regulated Cell Nutrition and Apoptosis

A Role for Rab7 GTPase in Growth Factor-Regulated Cell Nutrition and Apoptosis

When growth factors are removed from many mammalian cells, growth ceases and apoptosis is induced. The small GTPase rab7, which regulates endocytic membrane traffic, participates in this process by mediating the regulated internalization and degradation of nutrient transporters. This process trigger...

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Veröffentlicht in:Molecular Cell 2003-10, Vol.12 (4), p.796-797
1. Verfasser: Snider, Martin D
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apoptosis - physiology
Cell Division - physiology
Energy Metabolism - physiology
Growth Substances - physiology
Humans
Protein Transport - physiology
rab GTP-Binding Proteins - physiology
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Zusammenfassung:When growth factors are removed from many mammalian cells, growth ceases and apoptosis is induced. The small GTPase rab7, which regulates endocytic membrane traffic, participates in this process by mediating the regulated internalization and degradation of nutrient transporters. This process triggers nutrient starvation that helps to induce cell death.
ISSN:1097-2765
1097-4164
DOI:10.1016/S1097-2765(03)00401-5