A Concise and Flexible Total Synthesis of (−)-Diazonamide A

A Concise and Flexible Total Synthesis of (−)-Diazonamide A

The remarkable action of an IIII species on a tripeptide containing acyclic tyrosine/tryptophan is the key step in a total synthesis of (−)‐diazonamide A. The completed preparation of this new antimitotic is concise, multiply convergent, and amenable to diversification of intermediates.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2003-10, Vol.42 (40), p.4961-4966
Hauptverfasser: Burgett, Anthony W. G., Li, Qingyi, Wei, Qi, Harran, Patrick G.
Format: Artikel
Sprache:eng
Schlagworte:
antimitotic agents
Biological Factors - chemical synthesis
Biological Factors - chemistry
Heterocyclic Compounds, 4 or More Rings - chemical synthesis
Heterocyclic Compounds, 4 or More Rings - chemistry
Models, Molecular
Molecular Conformation
Molecular Structure
natural products
Oxazoles - chemical synthesis
Oxazoles - chemistry
oxidation
photochemistry
total synthesis
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Zusammenfassung:The remarkable action of an IIII species on a tripeptide containing acyclic tyrosine/tryptophan is the key step in a total synthesis of (−)‐diazonamide A. The completed preparation of this new antimitotic is concise, multiply convergent, and amenable to diversification of intermediates.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200352577