Primary non-Hodgkin lymphoma of the humerus following traumatic injury: case report

A case of primary non‐Hodgkin lymphoma of the right humerus which occurred in a 21‐year‐old male patient after an impact to the right shoulder in a car accident in July 1983 is described. Seventeen years after the injury, due to a civil lawsuit, the biopsy material was revised. Immunohistochemical analysis showed CD20 and CD79a positivity on large pleomorphic cells, while small reactive lymphocytes were CD3, Bcl‐2 and CD20 positive. Molecular analysis carried out with PCR revealed a monoclonal B‐lymphocyte population. The diagnosis of diffuse large peripheral B cell lymphoma of the bone was confirmed. The present case concurs with the literature on primary bone lymphoma, in which the diagnostic problem, trauma‐related presentation and an excellent prognosis of malignant tumour are emphasized. Copyright © 2003 John Wiley & Sons, Ltd.